Synthesis of vicinal aminoalcohols by stereoselective aza-Wacker cyclizations: access to (-)-acosamine by redox relay.
نویسندگان
چکیده
منابع مشابه
Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles
Aza-Heck cyclizations are an emerging method for the construction of chiral N-heterocyclic systems. In these processes, an activated N-O bond replaces the C-X bond (X = halide, OTf) used in conventional Heck reactions, with the associated aza-Pd(ii)-intermediate engaging pendant alkenes in a Heck-like manner. This perspective article commences with an historical overview of the area, which stem...
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In a Heck reaction using multi-substituted alkenes, the initial syn-carbopalladation sets two vicinal stereocenters by virtue of the migratory insertion process. Unfortunately, the resultant Pd–alkyl undergoes facile b-hydride elimination, which generally eliminates the stereochemistry imparted by migratory insertion. Recently, we have reported a modern variant of the Heck reaction, wherein the...
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 52 45 شماره
صفحات -
تاریخ انتشار 2013